Ex Vivo and In Vivo Study of Some Isoquinoline Precursors
نویسندگان
چکیده
This article concerns the synthesis and biological activities of some N-(1-(3,4-dimethoxyphenyl)propan-2-yl) amides as isoquinoline precursors compounds with smooth muscle (SM) relaxant activity. Aim: find activity compare it papaverine, an alkaloid that has been known a brain coronary vasodilator SM relaxant. Materials methods: In silico simulation PASS online program predicts for compounds. The were tested on isolated gastric preparations (SMPs) from rats to determine their effects spontaneous contractile (CA) compared papaverine. in vivo effect learning memory processes was also assessed. Results: data isometric measurements showed one caused ex relaxation circular tissues stomach (corpus) male Wistar rats. Conclusion: We found compound’s uses papaverine pathway. It improving cognitive functions
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ژورنال
عنوان ژورنال: Scientia Pharmaceutica
سال: 2022
ISSN: ['0036-8709', '2218-0532']
DOI: https://doi.org/10.3390/scipharm90020037